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Project website mtf.wiki
Translation license Creative Commons Attribution Share Alike 4.0 International
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  • Any authenticated user can contribute.
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Source code repository https://github.com/project-trans/MtF-wiki
Repository branch master
Last remote commit 贺莹: 更新流程细节 e65392a
Cryolitia PukNgae authored yesterday
Last commit in Weblate Merge remote-tracking branch 'origin/master' ddacc4b
Weblate authored yesterday
Weblate repository https://weblate.project-trans.org/git/mtf-wiki/main/
File mask content/*/docs/medicine/antiandrogen/cyproterone/index.md
Monolingual base language file content/zh-cn/docs/medicine/antiandrogen/cyproterone/index.md
Translation file Download content/zh-cn/docs/medicine/antiandrogen/cyproterone/index.md
Last change March 11, 2025, 2:48 p.m.
Last change made by None
Language Chinese (Simplified Han script)
Language code zh_Hans
Text direction Left to right
Number of speakers 1,286,095,292
Number of plurals 1
Plural type None
Plurals
Plural formula 0
3 days ago

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Total 34 2,153 7,677
Translated 100% 34 100% 2,153 100% 7,677
Needs editing 0% 0 0% 0 0% 0
Read-only 100% 34 100% 2,153 100% 7,677
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Untranslated strings 0% 0 0% 0 0% 0
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{{< /notice >}}
{{< /notice >}}
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<https://www.its.gov.tr/its/ilac_sorgula>
<https://www.its.gov.tr/its/ilac_sorgula>
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在土耳其生产的Androcur可以通过土耳其药品追踪系统查询信息：
在土耳其生产的Androcur可以通过土耳其药品追踪系统查询信息：
3 days ago
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{{< notice info >}}
{{< notice info >}}
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The “content/zh-cn/docs/medicine/antiandrogen/cyproterone/index.md” file was changed. a month ago
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[^1]: Wikipedia. Chlormadinone acetate [EB/OL]. (2023-11-25)[2024-05-01]. <https://en.wikipedia.org/wiki/Chlormadinone_acetate>
[^2]: Aly. Low Doses of Cyproterone Acetate Are Maximally Effective for Testosterone Suppression in Transfeminine People [EB/OL]. *Transfeminine Science*, 2019. 译文：《[低剂量的醋酸环丙孕酮足以最大限度地抑制女性倾向跨性别者的睾酮水平](https://tfsci.mtf.wiki/articles/cpa-dosage/)》
[^3]: Sadock B J, Ahmad S, Sadock V A. Kaplan and Sadock's Pocket Handbook of Clinical Psychiatry [M]. 6th ed. Philadelphia, US: Wolters Kluwer, 2018: 92.
[^4]: Ramsay I D, Rushton D H. Reduced serum vitamin B12 levels during oral cyproterone-acetate and ethinyl-oestradiol therapy in women with diffuse androgen-dependent alopecia [J]. *Clinical and Experimental Dermatology*, 1990, 15(4): 277–281. DOI: [10.1111/j.1365-2230.1990.tb02089.x](https://doi.org/10.1111/j.1365-2230.1990.tb02089.x)
[^5]: [醋酸环丙孕酮（新西兰 Siterone）说明书](https://tfsci.mtf.wiki/misc/siterone-nz/)
[^6]: [醋酸环丙孕酮（台湾 Androcur）说明书](https://tfsci.mtf.wiki/misc/androcur-tw/)
[^7]: Aly. Recent Developments on Cyproterone Acetate and Meningioma Risk Out of France and Implications for Transfeminine People [EB/OL]. *Transfeminine Science*, 2020. 译文：《[法国关于醋酸环丙孕酮和脑膜瘤风险的研究的最新进展以及对女性倾向跨性别者的影响](https://tfsci.mtf.wiki/articles/cpa-meningioma/)》
[^8]: Coleman E, Radix A E, Bouman W P, et al. Standards of Care for the Health of Transgender and Gender Diverse People, Version 8 [J]. *International Journal of Transgender Health*, 2022, *23*(Suppl 1): S1–S259. DOI: [10.1080/26895269.2022.2100644](https://doi.org/10.1080/26895269.2022.2100644) ——[中文译本](https://project-trans.org/SOC-8)
[^9]: Stahnke N, Ilicki A, Willig R P. Effect of Cyproterone Acetate (CA) on Growth and Endocrine Function in Precocious Puberty [J]. *Acta Paediatrica*, 1979, 68(S277): 32–40. DOI: [10.1111/j.1651-2227.1979.tb06189.x](https://doi.org/10.1111/j.1651-2227.1979.tb06189.x)
[^10]: Warzywoda S, Fowler J A, Bisshop F, et al. How low can you go? Titrating the lowest effective dose of cyproterone acetate for transgender and gender diverse people who request feminizing hormones [EB/OL]. *International Journal of Transgender Health*, (2024-02-20). DOI: [10.1080/26895269.2024.2317395](https://doi.org/10.1080/26895269.2024.2317395)
[^11]: Aly. Considerations in Understanding the Possible Role and Influence of Progestogens in Terms of Breast Development [EB/OL]. *Transfeminine Science*, 2020. 译文：《[关于孕激素在乳房发育过程中有何潜在作用及影响的随笔](https://tfsci.mtf.wiki/articles/progestogens-breast-dev/)》
[^12]: Yuk J-S. Relationship between menopausal hormone therapy and breast cancer: A nationwide population-based cohort study [EB/OL]. *International Journal of Gynecology & Obstetrics*, (2024-03-12). DOI: [10.1002/ijgo.15461](https://doi.org/10.1002/ijgo.15461)
[^13]: Seaman H E, de Vries C S, Farmer R D T. The risk of venous thromboembolism in women prescribed cyproterone acetate in combination with ethinyl estradiol: a nested cohort analysis and case–control study [J]. *Human Reproduction*, 2003, 18(3): 522–526. DOI: [10.1093/humrep/deg120](https://doi.org/10.1093/humrep/deg120)
[^14]: Seaman H E, Langley S E M, Farmer R D T, et al. Venous thromboembolism and cyproterone acetate in men with prostate cancer: a study using the General Practice Research Database [J]. *BJU International*, 2007, 99(6): 1398–1403. DOI: [10.1111/j.1464-410X.2007.06859.x](https://doi.org/10.1111/j.1464-410X.2007.06859.x)
[^15]: Kumari G L, Das R P, Madoiya K K, et al. Effect of short-term cyclic administration of cyproterone acetate on pituitary-ovarian function in the human [J]. *Fertility and sterility*, 1977, 28(11): 1168–1174. DOI: [10.1016/S0015-0282(16)42912-2](https://doi.org/10.1016/S0015-0282(16)42912-2)
[^1]: Wikipedia. Chlormadinone acetate [EB/OL]. (2023-11-25)[2024-05-01]. <https://en.wikipedia.org/wiki/Chlormadinone_acetate>
[^2]: Aly. Low Doses of Cyproterone Acetate Are Maximally Effective for Testosterone Suppression in Transfeminine People [EB/OL]. *Transfeminine Science*, 2019. 译文：《[低剂量的醋酸环丙孕酮足以最大限度地抑制女性倾向跨性别者的睾酮水平](https://tfsci.mtf.wiki/articles/cpa-dosage/)》
[^3]: Sadock B J, Ahmad S, Sadock V A. Kaplan and Sadock's Pocket Handbook of Clinical Psychiatry [M]. 6th ed. Philadelphia, US: Wolters Kluwer, 2018: 92.
[^4]: Ramsay I D, Rushton D H. Reduced serum vitamin B12 levels during oral cyproterone-acetate and ethinyl-oestradiol therapy in women with diffuse androgen-dependent alopecia [J]. *Clinical and Experimental Dermatology*, 1990, 15(4): 277–281. DOI: [10.1111/j.1365-2230.1990.tb02089.x](https://doi.org/10.1111/j.1365-2230.1990.tb02089.x)
[^5]: [醋酸环丙孕酮（新西兰 Siterone）说明书](https://tfsci.mtf.wiki/misc/siterone-nz/)
[^6]: [醋酸环丙孕酮（台湾 Androcur）说明书](https://tfsci.mtf.wiki/misc/androcur-tw/)
[^7]: Aly. Recent Developments on Cyproterone Acetate and Meningioma Risk Out of France and Implications for Transfeminine People [EB/OL]. *Transfeminine Science*, 2020. 译文：《[法国关于醋酸环丙孕酮和脑膜瘤风险的研究的最新进展以及对女性倾向跨性别者的影响](https://tfsci.mtf.wiki/articles/cpa-meningioma/)》
[^8]: Coleman E, Radix A E, Bouman W P, et al. Standards of Care for the Health of Transgender and Gender Diverse People, Version 8 [J]. *International Journal of Transgender Health*, 2022, *23*(Suppl 1): S1–S259. DOI: [10.1080/26895269.2022.2100644](https://doi.org/10.1080/26895269.2022.2100644) ——[中文译本](https://project-trans.org/SOC-8)
[^9]: Stahnke N, Ilicki A, Willig R P. Effect of Cyproterone Acetate (CA) on Growth and Endocrine Function in Precocious Puberty [J]. *Acta Paediatrica*, 1979, 68(S277): 32–40. DOI: [10.1111/j.1651-2227.1979.tb06189.x](https://doi.org/10.1111/j.1651-2227.1979.tb06189.x)
[^10]: Warzywoda S, Fowler J A, Bisshop F, et al. How low can you go? Titrating the lowest effective dose of cyproterone acetate for transgender and gender diverse people who request feminizing hormones [EB/OL]. *International Journal of Transgender Health*, (2024-02-20). DOI: [10.1080/26895269.2024.2317395](https://doi.org/10.1080/26895269.2024.2317395)
[^11]: Aly. Considerations in Understanding the Possible Role and Influence of Progestogens in Terms of Breast Development [EB/OL]. *Transfeminine Science*, 2020. 译文：《[关于孕激素在乳房发育过程中有何潜在作用及影响的随笔](https://tfsci.mtf.wiki/articles/progestogens-breast-dev/)》
[^12]: Yuk J-S. Relationship between menopausal hormone therapy and breast cancer: A nationwide population-based cohort study [EB/OL]. *International Journal of Gynecology & Obstetrics*, (2024-03-12). DOI: [10.1002/ijgo.15461](https://doi.org/10.1002/ijgo.15461)
[^13]: Seaman H E, de Vries C S, Farmer R D T. The risk of venous thromboembolism in women prescribed cyproterone acetate in combination with ethinyl estradiol: a nested cohort analysis and case–control study [J]. *Human Reproduction*, 2003, 18(3): 522–526. DOI: [10.1093/humrep/deg120](https://doi.org/10.1093/humrep/deg120)
[^14]: Seaman H E, Langley S E M, Farmer R D T, et al. Venous thromboembolism and cyproterone acetate in men with prostate cancer: a study using the General Practice Research Database [J]. *BJU International*, 2007, 99(6): 1398–1403. DOI: [10.1111/j.1464-410X.2007.06859.x](https://doi.org/10.1111/j.1464-410X.2007.06859.x)
[^15]: Kumari G L, Das R P, Madoiya K K, et al. Effect of short-term cyclic administration of cyproterone acetate on pituitary-ovarian function in the human [J]. *Fertility and sterility*, 1977, 28(11): 1168–1174. DOI: [10.1016/S0015-0282(16)42912-2](https://doi.org/10.1016/S0015-0282(16)42912-2)
a month ago
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- **脑膜瘤风险**：色普龙可能诱发脑膜瘤，风险与剂量和使用时长正相关。建议尽可能以更小剂量服用；如累积剂量已很大（高于 10 g），建议进行核磁共振扫描（MRI）[^7]。
- **精神疾病**：色普龙可能导致抑郁风险升高。主要原因是色普龙对于生理男性起到了抗雄激素和潜在的糖皮质激素作用，并可能诱发维生素 B<sub>12</sub> 缺乏[^4]，而维生素 B<sub>12</sub> 的缺乏和多种精神/情绪状况的改变有关，包括抑郁[^3]。有必要适量补充维生素 B<sub>12</sub>。
- **高血压**与**高血糖**：色普龙可能会提高体内胰岛素抗性，从而引起血糖偏高[^9]。糖尿病患者应慎用，用药时抗糖尿病制剂或胰岛素的需求可能改变；并发血管病变时禁用[^6]。
- **血栓**与**乳腺癌风险**：与雌激素合用时可一定程度提高其风险[^12] [^13]。此外，也有色普龙单药引起更高的血栓风险之报告[^14]。
- **高泌乳素水平**：可明显增加泌乳素水平，且随剂量上升，严重时可引起**垂体泌乳素瘤**。应定期检查泌乳素水平[^2]。
- **肝毒性**：色普龙最严重的副作用，与剂量相关，表现为肝转化酶水平升高；严重时可引起**肝衰竭**甚至**死亡**[^2] [^5] [^6]。使用前应当检查**肝功能**，使用时定期检查[^5]。
- {{< tag/neg "暂未明确" >}} 过早导入色普龙（尤其高剂量）可能造成乳房发育不良[^11]。
- **脑膜瘤风险**：色普龙可能诱发脑膜瘤，风险与剂量和使用时长正相关。建议尽可能以更小剂量服用；如累积剂量已很大（高于 10 g），建议进行核磁共振扫描（MRI）[^7]。
- **精神疾病**：色普龙可能导致抑郁风险升高。主要原因是色普龙对于生理男性起到了抗雄激素和潜在的糖皮质激素作用，并可能诱发维生素 B<sub>12</sub> 缺乏[^4]，而维生素 B<sub>12</sub> 的缺乏和多种精神/情绪状况的改变有关，包括抑郁[^3]。有必要适量补充维生素 B<sub>12</sub>。
- **高血压**与**高血糖**：色普龙可能会提高体内胰岛素抗性，从而引起血糖偏高[^9]。糖尿病患者应慎用，用药时抗糖尿病制剂或胰岛素的需求可能改变；并发血管病变时禁用[^6]。
- **血栓**与**乳腺癌风险**：与雌激素合用时可一定程度提高其风险[^12] [^13]。此外，也有色普龙单药引起更高的血栓风险之报告[^14]。
- **高泌乳素水平**：可明显增加泌乳素水平，且随剂量上升，严重时可引起**垂体泌乳素瘤**。应定期检查泌乳素水平[^2]。
- **肝毒性**：色普龙最严重的副作用，与剂量相关，表现为肝转化酶水平升高；严重时可引起**肝衰竭**甚至**死亡**[^2] [^5] [^6]。使用前应当检查**肝功能**，使用时定期检查[^5]。
- {{< tag/neg "暂未明确" >}} 过早导入色普龙（尤其高剂量）可能造成乳房发育不良[^11]。
a month ago
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The “content/zh-cn/docs/medicine/antiandrogen/cyproterone/index.md” file was changed. 2 months ago
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```csv
城市,药店,备注
南京,南京市秦淮区文昌巷13号邻客智慧药房,可以快递发货
合肥,合肥市蜀山区宿松路3666号国控宿繁店,
```
```csv
城市,药店,备注
南京,南京市秦淮区文昌巷13号邻客智慧药房,可以快递发货
合肥,合肥市蜀山区宿松路3666号国控宿繁店,
```
2 months ago
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